Leptin and ghrelin: Sewing metabolism onto neurodegeneration
Paola de Candia ; Giuseppe Matarese ; - ASI Sponsor
Dec - 2017
DOI: 10.1016/j.neuropharm.2017.12.025

journal : Neuropharmacology
type: Article Journal

Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin.

keywords : neurodegeneration, neuroinflammation, metabolism,leptin, ghrelin

Notes : Acknowledgements [...] GM is supported by the Italian Space Agency (ASI, 2014-033-R.O) [...]