Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction.
Liotta, Francesco ; Frosali, Francesca ; Querci, Valentina ; et al. ; - ASI Sponsor
Apr - 2008
ISSN : 1097-6825 ;
journal : The Journal of allergy and clinical immunology
Issue : 4
type: Article Journal
Abstract
The mechanisms by which human dendritic cells (DCs) activate a TH1-polarizing or TH2-polarizing program are still partially unclear.
keywords : CD4-Positive T-Lymphocytes,CD4-Positive T-Lymphocytes: immunology,CD4-Positive T-Lymphocytes: metabolism,Calcium-Binding Proteins,Calcium-Binding Proteins: metabolism,Calcium-Binding Proteins: physiology,Cell Communication,Cell Communication: immunology,Cell Differentiation,Cell Differentiation: immunology,Cells,Cultured,Dendritic Cells,Dendritic Cells: cytology,Dendritic Cells: immunology,Dendritic Cells: metabolism,GATA3 Transcription Factor,GATA3 Transcription Factor: biosynthesis,GATA3 Transcription Factor: genetics,Humans,Immunophenotyping,Intercellular Signaling Peptides and Proteins,Intercellular Signaling Peptides and Proteins: met,Intercellular Signaling Peptides and Proteins: phy,Membrane Proteins,Membrane Proteins: metabolism,Membrane Proteins: physiology,Myeloid Progenitor Cells,Myeloid Progenitor Cells: cytology,Myeloid Progenitor Cells: immunology,Myeloid Progenitor Cells: metabolism,Notch,Notch: metabolism,Notch: physiology,Receptors,T-Box Domain Proteins,T-Box Domain Proteins: biosynthesis,T-Box Domain Proteins: genetics,Th2 Cells,Th2 Cells: cytology,Th2 Cells: immunology,Th2 Cells: metabolism,Up-Regulation,Up-Regulation: genetics,Up-Regulation: immunology