Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats.
Nucci, Carlo ; Gasperi, Valeria ; Tartaglione, Rosanna ; et al. ; - ASI Sponsor
Jul - 2007
ISSN : 0146-0404 ;
journal : Investigative ophthalmology \& visual science

Issue : 7
type: Article Journal

Abstract
To evaluate whether high intraocular pressure (IOP)-induced ischemia is associated with modifications in the retinal endocannabinoid metabolism and to ascertain whether drugs that interfere with the endocannabinoid system may prevent retinal damage due to ischemic insult.

keywords : Amidohydrolases,Amidohydrolases: antagonists \& inhibitors,Amidohydrolases: metabolism,Animals,Antigens,Arachidonic Acids,Arachidonic Acids: metabolism,Benzamides,Benzamides: pharmacology,CB1,CB1: antagonists \& inhibito,CB1: metabolism,Cannabinoid,Capsaicin,Capsaicin: analogs \& derivatives,Capsaicin: pharmacology,Carbamates,Carbamates: pharmacology,Cell Count,Chromatography,Endocannabinoids,Endocannabinoids: physiology,Enzyme Inhibitors,Enzyme Inhibitors: pharmacology,Enzyme-Linked Immunosorbent Assay,High Pressure Liquid,Hydrolysis,Intraocular Pressure,Male,Messenger,Messenger: metabolism,Ocular Hypertension,Ocular Hypertension: complications,Piperidines,Piperidines: pharmacology,Polyunsaturated Alkamides,Polyunsaturated Alkamides: metabolism,Pyrazoles,Pyrazoles: pharmacology,RNA,Rats,Receptor,Reperfusion Injury,Reperfusion Injury: etiology,Reperfusion Injury: metabolism,Reperfusion Injury: pathology,Reperfusion Injury: prevention \& control,Retinal Diseases,Retinal Diseases: etiology,Retinal Diseases: metabolism,Retinal Diseases: pathology,Retinal Diseases: prevention \& control,Retinal Ganglion Cells,Retinal Ganglion Cells: pathology,Retinal Vessels,Retinal Vessels: metabolism,Reverse Transcriptase Polymerase Chain Reaction,Sprague-Dawley,TRPV Cation Channels,TRPV Cation Channels: antagonists \& inhibitors,TRPV Cation Channels: metabolism,Thy-1,Thy-1: genetics